A | 阿尔茨海默病（AD）是一种使人衰弱的渐进性疾病，开始时是轻微的记忆丧失，慢慢地破坏了认知功能和记忆。它目前没有治愈方法，预计到2050年将影响全球1亿多人。 Kartik Aaryan is all set to join the guest line-up at the Red Sea International Film Festival 2025. The festival will be taking place in Jeddah, Saudi Arabia. He has been invited as a special guest on “In Conversation”. The actor will be joining renowned names such as Idris Elba, Anthony Hopkins, Nicholas Hoult, Riz Ahmed, Darren Aronofsky and Edgar Ramirez. Kartik Aaryan first gained widespread attention with Pyaar Ka Punchnama. His monologue went viral. Post that, he has gone on to do successful films like Bhool Bhulaiyaa 2, Dhamaka, Freddy and Chandu Champion. His versatility has been lauded by the audience. With his upcoming releases, he continues to branch out to different genres. View this post on Instagram A post shared by KARTIK AARYAN (@kartikaaryan) Earlier this year, he received his first Filmfare Best Actor Award for his work in the film Chandu Champion. He celebrated the win with an emotional post on Instagram, which read, “From the days I only watched the black lady on TV…to holding her in my hands — this one’s for every dreamer who refuses to give up.” His “In Conversation” session at the Red Sea International Film Festival will reportedly focus on his approach to acting. The actor will also share his experience working across varied genres and his perspective on the shifting landscape of Indian cinema as it engages with global audiences. View this post on Instagram A post shared by KARTIK AARYAN (@kartikaaryan) On the professional front, Kartik Aaryan is all set for his Christmas release, Tu Meri Main Tera Main Tera Tu Meri. Ananya Pandey will be joining him for the second time after Pati Patni Aur Woh. He is also set to star in the upcoming thriller Naagzilla, which is gearing up for a 2026 release. Also Read: Photos: Kartik Aaryan Shares Unmissable Portraits From His Sister’s Wedding, Pens Emotional Note。在美国，根据国家老龄化研究所的数据，AD是老年人痴呆的主要原因，也是第七大最常见的死亡原因。正在进行的阿尔茨海默氏症研究集中在两个关键的神经毒性蛋白上：淀粉样β（Aβ）和tau。
B | 尽管这些蛋白质已被证明与AD有关，但Aβ和tau的水平并不能持续解释或与一些疾病患者的认知能力下降的严重程度相关。作为麻省总医院布里格姆医疗系统的创始成员之一，布里格姆妇女医院的研究人员着手确定其他可能直接参与AD基本方面的蛋白质，如突触损失和神经变性。他们将实验室的神经元暴露在大约40人的大脑提取物中，这些人要么患有AD，要么在Aβ和tau水平较高的情况下受到保护，要么在大脑中很少或没有Aβ和tau时受到保护。科学家们发现并验证了神经节苷脂GM2激活剂（GM2A）是一种能够减少神经元发射并诱发神经元完整性丧失的蛋白质。这些蛋白质的特征可能有助于AD的病因、疾病的进展，或两者都有。
C | 高级作者、神经学系的Tracy Young-Pearse博士说："我们的数据有助于确定一种可能与阿尔茨海默病的发病机制有关的新的和潜在的重要蛋白质。有趣的是，GM2A以前被认为是一种与Tay-Sachs病非常相似的溶酶体储存障碍的致病因素，Tay-Sachs病是另一种像AD一样破坏神经元的疾病。
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